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N‑Heterocyclic Carbene-Catalyzed Enantioselective Intramolecular N‑Tethered Aldehyde–Ketone Benzoin Reactions

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journal contribution
posted on 19.02.2016, 13:10 by Min-Qiang Jia, Shu-Li You
The N-heterocyclic carbene-catalyzed enantioselective intramolecular benzoin reaction of N-tethered substrates was realized. With 15 mol % of d-camphor-derived triazolium salt E and 10 mol % of NaOAc, the aldehyde–ketone cross benzoin reactions of various substituted N-tethered substrates proceeded smoothly to afford dihydroquinolinone derivatives with a quaternary carbon stereocenter in moderate to good yields and excellent ee.