posted on 2024-01-17, 20:07authored byGuoxi Qiu, Wentao Zhou, Yupeng Liu, Tingting Meng, Fangying Yu, Xiangyu Jin, Keke Lian, Xueqing Zhou, Hong Yuan, Fuqiang Hu
Thermosensitive nanoparticles can be activated by externally
applying
heat, either through laser irradiation or magnetic fields, to trigger
the release of drug payloads. This controlled release mechanism ensures
that drugs are specifically released at the tumor site, maximizing
their effectiveness while minimizing systemic toxicity and adverse
effects. However, its efficacy is limited by the low concentration
of drugs at action sites, which is caused by no specific target to
tumor sties. Herein, hyaluronic acid (HA), a gooey, slippery substance
with CD44-targeting ability, was conjugated with a thermosensitive
polymer poly(acrylamide-co-acrylonitrile) to produce
tumor-targeting and thermosensitive polymeric nanocarrier (HA-P) with
an upper critical solution temperature (UCST) at 45 °C, which
further coloaded chemo-drug doxorubicin (DOX) and photosensitizer
Indocyanine green (ICG) to prepare thermosensitive nanoreactors HA-P/DOX&ICG.
With photosensitizer ICG acting as the “temperature control
element”, HA-P/DOX&ICG nanoparticles can respond to temperature
changes when receiving near-infrared irradiation and realize subsequent
structure depolymerization for burst drug release when the ambient
temperature was above 45 °C, achieving programmable and on-demand
drug release for effective antitumor therapy. Tumor inhibition rate
increased from 61.8 to 95.9% after laser irradiation. Furthermore,
the prepared HA-P/DOX&ICG nanoparticles possess imaging properties,
with ICG acting as a probe, enabling real-time monitoring of drug
distribution and therapeutic response, facilitating precise treatment
evaluation. These results provide enlightenment for the design of
active tumor targeting and NIR-triggered programmable and on-demand
drug release of thermosensitive nanoreactors for tumor therapy.