American Chemical Society
np9904511_si_001.pdf (201.57 kB)

Mycalamide D, a New Cytotoxic Amide from the New Zealand Marine Sponge Mycale Species

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journal contribution
posted on 2000-03-04, 00:00 authored by Lyndon M. West, Peter T. Northcote, Kylie A. Hood, John H. Miller, Michael J. Page
A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl group of mycalamide A (1) is replaced by a hydrogen atom, was found to be cytotoxic to a range of mammalian cell lines, with a potency approximately 20-fold less than that of 1.