Multivalent Aminosaccharide-Based Gold Nanoparticles as Narrow-Spectrum Antibiotics in Vivo
journal contributionposted on 04.02.2019, 00:00 by Xinglong Yang, Qin Wei, Huawu Shao, Xingyu Jiang
Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using d-glucosamine (GluN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
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aminosaccharide-based AuNPaminosaccharide-based gold nanoparticlesgold nanoparticlescombat MDR bacteriabacteria-induced wound infectionaminosaccharide-based AuNPssuperbug-infected woundNarrow-Spectrum Antibioticssuperbug-infected wound healingantibiotic resistancebroad-spectrum drugsMultivalent Aminosaccharide-Based Gold Nanoparticles