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Multipolymer Solution-Phase Reactions: Application to the Mitsunobu Reaction

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journal contribution
posted on 12.01.2005, 00:00 authored by Andrew M. Harned, Helen Song He, Patrick H. Toy, Daniel L. Flynn, Paul R. Hanson
The realization of the first polymer-on-polymer Mitsunobu reaction, in which a polymeric phosphine is used simultaneously with a polymeric azodicarboxylate, is reported. This strategy employs the use of soluble oligomers generated from ring-opening methathesis polymerization. 31P NMR analysis revealed that the two polymers were interacting to generate the Mitsunobu products. Application to several substrates, as well as comparison experiments with other polymeric reagents, is described.