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Download fileMultifunctional Tissue-Adhesive Cryogel Wound Dressing for Rapid Nonpressing Surface Hemorrhage and Wound Repair
journal contribution
posted on 29.07.2020, 19:04 authored by Meng Li, Zhiyi Zhang, Yongping Liang, Jiahui He, Baolin GuoCryogels with tissue adhesion have
great potential as wound dressings
for rapid hemostasis for uncontrollable nonpressing surface hemorrhage
and wound healing, but their use has not been reported previously.
Herein, we designed a series of antibacterial and antioxidant tissue-adhesive
cryogels based on quaternized chitosan (QCS) and polydopamine (PDA).
These cryogels had good blood cell and platelet adhesion, enrichment,
and activation properties for rapid nonpressing surface hemostasis
and wound healing. The cryogels exhibited outstanding mechanical strength
and easy removability, antioxidant activity, and NIR photothermal-enhanced
antibacterial performance. The cryogels showed much better hemostasis
than gauze and gelatin sponge in a standardized strip rat liver injury
model, a standardized circular rabbit liver section model, and a pig
skin laceration model. Furthermore, the excellent hemostatic performance
of the QCS/PDA2.0 cryogel (containing 20 mg/mL QCS and 2.0 mg/mL PDA)
for coagulopathic hemorrhages was confirmed in a standardized coagulation
disorder rabbit circular liver section model. In addition, the QCS/PDA2.0
cryogel promoted rapid hemostasis in a deep noncompressible wound
and a much better wound healing effect than a chitosan sponge and
Tegaderm film in a full-thickness skin defect model. Overall, these
multifunctional tissue-adhesive cryogels with excellent hemostatic
performance and enhanced wound healing properties are suitable candidates
for tissue-adhesive hemostat and wound healing dressings.
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rabbit liver section modelliver section modelantioxidant tissue-adhesive cryogelsMultifunctional Tissue-Adhesive Cry...nonpressing surface hemostasisnonpressing surface hemorrhageWound Repair CryogelsNIRwound healing propertieshemostatic performancewound healing effectstrip rat liver injury modelwound healingmultifunctional tissue-adhesive cry...PDAQCScoagulation disorder rabbitfull-thickness skin defect modelpig skin laceration modelRapid Nonpressing Surface Hemorrhagewound healing dressings