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Multicomponent Synthesis of Fused Benzimidazolopiperazines

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journal contribution
posted on 03.06.2011, 00:00 by Laurent El Kaïm, Laurence Grimaud, Srinivas Reddy Purumandla
We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi–Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation.