American Chemical Society
ol202472z_si_002.pdf (4.14 MB)

Multicomponent Catalytic Asymmetric Aziridination of Aldehydes

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journal contribution
posted on 2016-02-22, 17:20 authored by Anil K. Gupta, Munmun Mukherjee, William D. Wulff
The first multicomponent catalytic asymmetric aziridination reaction is developed to give aziridine-2-carboxylic esters with very high diastereo- and enantioselectivity from aromatic and aliphatic aldehydes. This new method pushes the boundary of the aziridination reaction to substrates that failed with preformed imines.