Multicomponent Assembly
of Trisubstituted Imidazoles
and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds

Gapanenok, Diana; Makhmet, Azat; Peshkov, Anatoly A.; Smirnova, Darya; Amire, Niyaz; Peshkov, Vsevolod A.; Spiridonova, Darya; Dar’in, Dmitry; Balalaie, Saeed; Krasavin, Mikhail

doi:10.1021/acs.joc.2c00475.s001

Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds

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posted on 2022-06-08, 16:04 authored by Diana Gapanenok, Azat Makhmet, Anatoly A. Peshkov, Darya Smirnova, Niyaz Amire, Vsevolod A. Peshkov, Darya Spiridonova, Dmitry Dar’in, Saeed Balalaie, Mikhail Krasavin

A straightforward route to a large and diverse library of trisubstituted imidazoles was established via a three-component reaction of 2-oxoaldehydes, 1,3-dicarbonyl compounds, and acyclic nitrogen bis-nucleophiles. The obtained products were subsequently explored in a photochemical cyclization yielding a variety of imidazole-fused polycyclic compounds.

Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds

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