posted on 2019-08-12, 15:09authored byLian-Feng Fan, Pu-Sheng Wang, Liu-Zhu Gong
Monodentate phosphorus
ligands have been found to enable the palladium-catalyzed
allylic C–H alkylation reaction of terminal alkenes with a
wide variety of carbon nucleophiles. Moreover, an asymmetric allylic
C–H alkylation of terminal alkenes with pyrazol-5-ones has
been established in the presence of chiral phosphoramidite ligand
and chiral phosphoric acid as co-catalyst. Mechanistic studies suggest
that a ternary Pd(0) complex, coordinated with a monodentate phosphorus
ligand, benzoquinone, and alkene, is most likely to be an active species.