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Monocarboxylation and Intramolecular Coupling of Butenylated Arenes via Palladium-Catalyzed C–H Activation Process

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journal contribution
posted on 20.03.2015, 00:00 by Rui Liu, Ze-Hai Lu, Xiao-Hui Hu, Jun-Li Li, Xian-Jin Yang
A novel and practical reaction for the direct intramolecular oxidative coupling of butenylated arenes is reported. With the catalysis of Pd­(OAc)2, reactions of various butenylated arenes and carboxylic acids with Selectfluor reagent in CH3CN solution afforded the corresponding monocarboxylation/cyclization products in good yields under mild conditions. This research demonstrated an economic method with the synthesis of 2-tetralyl carboxylic esters, a valuable class of bioactive compounds.