Monocarboxylation and Intramolecular Coupling of Butenylated Arenes via Palladium-Catalyzed C–H Activation Process
journal contribution
posted on 2015-03-20, 00:00 authored by Rui Liu, Ze-Hai Lu, Xiao-Hui Hu, Jun-Li Li, Xian-Jin YangA novel
and practical reaction for the direct intramolecular oxidative coupling
of butenylated arenes is reported. With the catalysis of Pd(OAc)<sub>2</sub>, reactions of various butenylated arenes and carboxylic acids
with Selectfluor reagent in CH<sub>3</sub>CN solution afforded the
corresponding monocarboxylation/cyclization products in good yields
under mild conditions. This research demonstrated an economic method
with the synthesis of 2-tetralyl carboxylic esters, a valuable class
of bioactive compounds.
