Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed
Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Toscani, Anita; Risi, Caterina; W. Black, Gary; Brown, Nicola L.; Shaaban, Ali; Turner, Nicholas J.; Castagnolo, Daniele

doi:10.1021/acscatal.8b02386.s001

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

journal contribution

posted on 2018-08-07, 00:00 authored by Anita Toscani, Caterina Risi, Gary W. Black, Nicola L. Brown, Ali Shaaban, Nicholas J. Turner, Daniele Castagnolo

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ ¹⁹F NMR.