American Chemical Society
cs8b02386_si_001.pdf (2.44 MB)

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

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journal contribution
posted on 2018-08-07, 00:00 authored by Anita Toscani, Caterina Risi, Gary W. Black, Nicola L. Brown, Ali Shaaban, Nicholas J. Turner, Daniele Castagnolo
A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.