posted on 2016-02-12, 00:00authored bySunitha Meruvu, Jian Zhang, Mahua Choudhury
Phthalates, an endocrine
disruptor group, cause oxidative stress
(OS) in the placenta. However, no studies have reported OS-related
miRNAs induced by phthalates. In the present study, we demonstrate
that mono-(2-ethylhexyl) phthalate (MEHP) induces OS responsive miR-17-5p,
miR-155-5p, and miR-126-3p in HTR8/SVneo in a dose- and time-dependent
manner. Furthermore, MEHP altered the expression of phosphoinositide-3-kinase
regulatory subunit 1α, phosphatase and tensin homolog, CDKN2A
interacting protein, superoxide dismutase 2, and 3β-hydroxysterol-D24
reductase, which are involved in OS and predicted to be regulated
by these miRNAs. Our results suggest that placental exposure to MEHP
may result in aberrant miRNA expression leading to pregnancy complications.