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Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.

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journal contribution
posted on 27.03.2015, 00:00 by Weihong Wang, Tae Gu Lee, Rahul S. Patil, Bora Mun, Inho Yang, Hiyoung Kim, Dongyup Hahn, Dong Hwan Won, Jihye Lee, Yehee Lee, Hyukjae Choi, Sang-Jip Nam, Heonjoong Kang
Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (13). Compounds 1 and 2, designated as monanchosterols A and B, respectively, represent the first examples of steroids possessing the bicyclo[4.3.1] A/B ring system from a natural source. Compounds 13 were investigated for their anti-inflammatory activity by evaluating their inhibitory effects on the mRNA expression of IL-6, TNF-α, and COX-2 in the LPS-stimulated murine RAW264.7 macrophage cells. Compounds 2 and 3 exhibited significant inhibitory effects on the mRNA expression of IL-6 without notable cytotoxicity to the cells in a dose-dependent manner.