Modulation of Photodeprotection by the Sunscreen Protocol
journal contributionposted on 06.02.2015, 00:00 by Or Eivgi, Efrat Levin, N. Gabriel Lemcoff
A protocol for the selective photoremoval of alcohol protecting groups modulated by the presence of auxiliary light absorbing molecules is presented. Thus, by this method, a single light source was used to selectively remove a specific protecting group in the presence of another chromophore with a lower molar absorption coefficient. The use of a molecular sunscreen, either internal or external, was found to be crucial to achieve high selectivities.