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Download fileModular Functionalization of Laminarin to Create Value-Added Naturally Derived Macromolecules
journal contribution
posted on 2020-11-09, 20:06 authored by Ana M.
S. Costa, João M. M. Rodrigues, Maria M. Pérez-Madrigal, Andrew P. Dove, João F. ManoWith society’s growing awareness
of climate change, novel
renewable and naturally sourced materials have received increasing
attention as substitutes for petroleum-based products. Laminarin (LAM–OH)
is a highly abundant, nontoxic, degradable polysaccharide found in
marine organisms and hence is a promising sustainable polymeric candidate.
This work reports on a simple, environmentally friendly, and customizable
functionalization strategy for producing a toolbox of LAM–OH
derivatives under mild conditions. Herein, natural-origin macromolecules
exhibiting specific chemical moieties, namely, allyl, amine, carboxylic
acid, thiol, aldehyde, and catechol, were prepared and chemically
characterized. Furthermore, the obtained polymers were processed into
cytocompatible hydrogels, obtained by employing distinct cross-linking
mechanisms, to assess their potential for biomedical purposes. The
application scope of such polymers could be extended to fields such
as catalysis, cosmetics, life sciences, and food packaging, which
can also benefit from having sustainable, nontoxic, and degradable
materials. Moreover, it is anticipated that the methodology employed
to create this library of new natural-based products could be adapted
to modify other polysaccharides and biopolymers in general.
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Keywords
chemical moietiesModular Functionalizationcross-linking mechanismssourced materialsderivativeawarenessLAMtoolboxmarine organismspetroleum-based productscustomizable functionalization strategyclimate changecarboxylic acidsubstitutedegradable polysaccharideLaminarinfood packagingcandidatework reportsnatural-origin macromoleculesnatural-based productscosmeticaminedegradable materialsallylcatalysicytocompatible hydrogelsthiolcatechollife sciencesbiopolymerpolymerValue-AddedmethodologyaldehydeDerived Macromoleculesapplication scopeHerein