Modular Approach for Synthesis of Vicinal Diamines Containing Axial Chiral 1,1′-Binaphthyl from 1,2-Diaminoethane by Pd-Catalyzed N-Arylation Reactions

A very convenient and efficient modular approach for the synthesis of vicinal diamines containing axial chiral 1,1′-binaphthyl from 1,2-diaminoethane by Pd-catalyzed N-arylation reactions has been developed. The resulting chiral diamines could be easily converted into NHC precursors, imidazole salts, in good yields.