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Modular Access to N‑Substituted cis-3,5-Diaminopiperidines

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journal contribution
posted on 06.12.2013, 00:00 authored by Aurélie Blond, Paul Dockerty, Raquel Álvarez, Serge Turcaud, Thomas Lecourt, Laurent Micouin
A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.