American Chemical Society
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Model Systems for Flavoenzyme Activity. Control of Flavin Recognition via Specific Electrostatic Interactions

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journal contribution
posted on 2001-04-20, 00:00 authored by Allan J. Goodman, Eric C. Breinlinger, Catherine M. McIntosh, Lisa N. Grimaldi, Vincent M. Rotello
A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.