posted on 2021-08-09, 12:07authored byJuanfeng Ou, Hao Tian, Juanyan Wu, Junbin Gao, Jiamiao Jiang, Kun Liu, Shuanghu Wang, Fei Wang, Fei Tong, Yicheng Ye, Lu Liu, Bin Chen, Xing Ma, Xuncai Chen, Fei Peng, Yingfeng Tu
Chemodynamic
therapy (CDT) is an emerging strategy for cancer treatment
based on Fenton chemistry, which can convert endogenous H2O2 into toxic ·OH. However, the limited endocytosis
of passive CDT nanoagents with low penetrating capability resulted
in unsatisfactory anticancer efficacy. Herein, we propose the successful
fabrication of a self-propelled biodegradable nanomotor system based
on hollow MnO2 nanoparticles with catalytic activity for
active Fenton-like Mn2+ delivery and enhanced CDT. Compared
with the passive counterparts, the significantly improved penetration
of nanomotors with enhanced diffusion is demonstrated in both the
2D cell culture system and 3D tumor multicellular spheroids. After
the intracellular uptake of nanomotors, toxic Fenton-like Mn2+ is massively produced by consuming overexpressed intracellular glutathione
(GSH), which has a strong scavenging effect on ·OH, thereby leading
to enhanced cancer CDT. The as-developed MnO2-based nanomotor
system with enhanced penetration and endogenous GSH scavenging capability
shows much promise as a potential platform for cancer treatment in
the near future.