Mn-Etched Zeolitic Imidazolate Framework-67 Nanostructures for Biomimetic Superoxide Anion Sensing
journal contributionposted on 2022-04-18, 20:08 authored by Fang Shi, Zhuanzhuan Shi, Zhuo Zou, Xiaoshuai Wu, Zhengyang Liu, Liang Liu, Qianqian Fu, Yuan Li, Wei Sun, Chunxian Guo, Chang Ming Li
It is a great challenge to detect superoxide anions (O2•–) with low level concentrations and short half-life in biological systems. Herein, mild and facile Mn etching for zeolitic imidazolate framework-67 (ZIF-67) was used to synthesize Mn/ZIF-67 with a hydrangea-like nanostructure for biomimetic sensing of O2•– released from living cells. The tailored optimal Mn/ZIF-67 sensor achieves a high selectivity, a fast response time (1.6 s), a broad linear detection range (1.5 nM–10 μM), an ultralow detection limit (0.8 nM), and a remarkably high sensitivity (439.2 μA μM–1 cm–2) that ranks the best among all reported conventional Mn- and Co-compound-based nanozymes such as Co2P and Mn3(PO4)2. The excellent sensing performances are attributed to the Mn etching-generating hydrangea-like nanostructure for a significantly increased reaction surface area and coordinating Mn2+ with Co2+ to raise the oxidation state of Co2+ for fast electron transfer during the oxidation of O2•–. This work holds great potential for a highly sensitive O2•– nanozyme sensor in practical clinical diagnosis and bioscience research, while shedding fundamental light on designs of sensitive nanozyme sensors by incorporating two metal ions with largely different negativity for an efficient electrocatalytic process, thereby possessing universal significance.
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zeolitic imidazolate frameworkultralow detection limitshedding fundamental lightpractical clinical diagnosislow level concentrationslargely different negativityfast response timefast electron transferefficient electrocatalytic processdetect superoxide anions2 μa μmremarkably high sensitivityexcellent sensing performancestailored optimal mnreported conventional mnsensitive nanozyme sensors8 nm ),2 </ sub2 +</ supfacile mn etching67 sensor achievesnanozyme sensormn etchinghighly sensitivehigh selectivitybiomimetic sensingsynthesize mncoordinating mnshort halfliving cellslike nanostructuregreat challengebioscience researchbiological systemsbest amongbased nanozymes67 nanostructures