Mixed Periodic Mesoporous Organosilica Nanoparticles and Core–Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery
journal contribution
posted on 2014-12-23, 00:00 authored by Jonas Croissant, Damien Salles, Marie Maynadier, Olivier Mongin, Vincent Hugues, Mireille Blanchard-Desce, Xavier Cattoën, Michel Wong Chi Man, Audrey Gallud, Marcel Garcia, Magali Gary-Bobo, Laurence Raehm, Jean-Olivier DurandIn this work, we describe the synthesis
of new Mixed Periodic Mesoporous
Organosilica Nanoparticles (MPMO NPs), combining the co-condensation
of a tetra-trialkoxysilylated two-photon photosensitizer with bis-(triethoxysilyl)phenylene
or ethylene. Novel gold core-MPMO shell systems are also described.
The MPMO NPs are analyzed and characterized by multiple techniques,
and are very efficient for anti-cancer drug delivery combined with
two-photon therapy in MCF-7 breast cancer cells, leading down to 76%
cancer cell death. MPMO NPs are thus very promising for nanomedicine
applications.
