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Mimicry of a β‑Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer

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journal contribution
posted on 13.06.2018, 00:00 by Joseph W. Meisel, Chunhua T. Hu, Andrew D. Hamilton
The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.