jo901019u_si_001.pdf (3.43 MB)
Download file

Microwave-Assisted Synthesis of Substituted Tetrahydropyrans Catalyzed by ZrCl4 and Its Application in the Asymmetric Synthesis of exo- and endo-brevicomin

Download (3.43 MB)
journal contribution
posted on 07.08.2009, 00:00 by Surendra Singh, Patrick J. Guiry
The ZrCl4-catalyzed deprotection of 1,3-dioxane/dioxalane and the simultaneous formation of 6-methoxy-substituted tetrahydropyrans proceeded under microwave irradiation in good yield. This synthetic methodology was used for the asymmetric synthesis of (+)-exo- and (+)-endo-brevicomin in 55% overall yield over 4 steps.

History