Phosphatidylserine
(PtdSer), one of the phospholipids that the
apoptotic cell exposes, has emerged for anti-inflammatory therapy via polarizing inflammatory microglia (Mi1) to anti-inflammatory
phenotype (Mi2). In this study, we report microglia polarization effect
of PtdSer-exposing polymeric particles (PSPs). PSPs upregulated Mi2
microglia and suppressed Mi1 microglia through peroxisome proliferator-activated
receptor gamma upregulation in vitro and in vivo. This study highlights the potential of PSPs for
anti-inflammatory therapy.