om8b00575_si_001.pdf (1.12 MB)
Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2‑Hydroxypyridylmethylene Fragment
journal contribution
posted on 2018-09-14, 12:20 authored by Danfeng Deng, Bowen Hu, Min Yang, Dafa ChenReaction of complex [Cp*Ir(HOC5H3CH2C5H3OH)Cl][Cl]
(1) with AgOTf generated the product [Cp*Ir(HOC5H3CH2C5H3OH)(H2O)][OTf]2 (2), which was further transformed
to the complex [Cp*Ir(OC5H3CH2C5H3O)(H2O)] (3) in the presence
of t-BuONa via −OH deprotonation. Complexes 1–3 exhibited high activity for the methylation
of amines and ketones. These C–C and C–N coupling reactions
proceeded in air with 1 mol % catalyst loading in the presence of
K2CO3.