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Methodology for Predicting OEL from Rodent LD50 Values for Metals and Metallic Compounds

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journal contribution
posted on 01.01.2005, 00:00 by Hidetaka Yanagida, Akihiro Yamasaki, Yukio Yanagisawa
The relationship between the occupational exposure limits (OEL) and the lethal dose 50 (LD50) values of rats or mice for metals and metallic compounds was statistically analyzed by a stepwise multivariate regression method. The OEL values were predicted from LD50 values and metallic compensation coefficients (MCC), which were developed as the regression coefficients of dummy variables that represented the metallic element contained in the substance of interest. The value of the MCC indicated the extent of the adverse health effects of the metal in the substance. Smaller values of the MCC were assigned to metals that would have the more severe adverse health effects, such as carcinogenesis, while larger values were given to the less toxic metals. The Health Index (HI) based on the OEL values was proposed as a convenient measure of the toxicity of industrial products. The prediction method could be applied to toxicity risk assessments by using the HI when a designer of consumer products wants to use substances for which OEL values have not been determined. Two case studies were conducted to estimate the potential toxicity of materials used in solders and in rechargeable batteries.