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Methimazole-Based Ionic Liquids

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journal contribution
posted on 20.06.2008, 00:00 authored by Amal I. Siriwardana, Ian R. Crossley, Angel A. J. Torriero, Iko M. Burgar, Noel F. Dunlop, Alan M. Bond, Glen B. Deacon, Douglas R. MacFarlane
The alkylation reaction of 2-mercapto-1-methylimidazole 1a with iodoethane and chlorobutane produced S-alkylmethimazole halides 2a and 2b which were subjected to anion metathesis with two different metal salts (MA) to afford methimazole-based room-temperature ionic liquids 3a, 3b, and 3c in 82%, 85%, and 87% yields, respectively. S-Alkylation giving 2a and 2b suggests that methimazole reacts through the thione tautomer.