American Chemical Society
ja305801m_si_001.pdf (1.5 MB)

Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF3SiMe3 and Elemental Sulfur

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journal contribution
posted on 2012-08-01, 00:00 authored by Chao Chen, Lingling Chu, Feng-Ling Qing
A metal-free oxidative trifluoromethyl-thiol­ation of terminal alkynes using readily available CF3SiMe3 and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant.