posted on 2023-09-29, 15:04authored byFang Fang, Jie Xia, Siying Quan, Shanping Chen, Guo-Jun Deng
A facile and practical approach for the preparation of
substituted
pyrimidines from ketones, NH4OAc, and N,N-dimethylformamide dimethyl acetal has been described.
This NH4I-promoted three-component tandem reaction affords
a broad range of substituted pyrimidines in acceptable yields under
metal- and solvent-free conditions. The present methodology features
the advantages of simple and easily available starting materials,
metal- and solvent-free conditions, a broad substrate scope with good
functional group tolerance, and gram-scale synthesis.