American Chemical Society
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Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH4I‑Promoted Three-Component Tandem Reaction

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journal contribution
posted on 2023-09-29, 15:04 authored by Fang Fang, Jie Xia, Siying Quan, Shanping Chen, Guo-Jun Deng
A facile and practical approach for the preparation of substituted pyrimidines from ketones, NH4OAc, and N,N-dimethylformamide dimethyl acetal has been described. This NH4I-promoted three-component tandem reaction affords a broad range of substituted pyrimidines in acceptable yields under metal- and solvent-free conditions. The present methodology features the advantages of simple and easily available starting materials, metal- and solvent-free conditions, a broad substrate scope with good functional group tolerance, and gram-scale synthesis.