ja7b01016_si_001.pdf (20.75 MB)
Download file

Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes

Download (41.5 MB)
journal contribution
posted on 15.02.2017, 00:00 by Peng Xiong, He-Huan Xu, Hai-Chao Xu
A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. The electrosynthetic method proceeds through radical cyclization to form the key C–N bond, allowing a variety of hindered tri- and tetrasubstituted olefins to participate in the amination reaction. The result is the efficient synthesis of a host of alkene-bearing cyclic carbamates and ureas and lactams.