A novel metal- and azide-free methodology
for the synthesis of
trifluoromethylated 1,2,3-triazoles from arylamines with a new 3-bromo-1,1,1-trifluoropropan-2-one
derived tosylhydrazone has been developed under mild reaction conditions.
The new α-bromo-trifluoromethylated tosylhydrazone reagent was
operationally safe and bench-stable from low-cost and readily commercially
available starting materials in the iodine-promoted aerobic oxidative
cycloaddition reaction with arylamines, affording a variety of trifluoromethylated
1,2,3-triazoles in good to excellent yields.