Metal-Free Visible-Light-Mediated Oxidative Cross-Coupling of Thiols with P(O)H Compounds Using Air as the Oxidant

Visible light along with 5 mol % of rose bengal catalyzes the direct S–P­(O) coupling between thiols and P­(O)H compounds in the presence of air as the green oxidant. The protocol is operationally simple and amenable to gram-scale synthesis. A variety of S–P­(O) coupling products can be readily prepared in moderate to excellent yields. The reaction features good functional-group tolerance, operational simplicity, and excellent practicality.