Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of Alkenyl Cyclobutanols with Ethynylbenziodoxolones
journal contributionposted on 08.08.2016, 15:23 by Ruo-Yi Zhang, Long-Yi Xi, Lei Shi, Xiao-Zhuan Zhang, Shan-Yong Chen, Xiao-Qi Yu
The first metal-free alkynylation/ring expansion cascade process of alkenyl cyclobutanols with ethynylbenziodoxolones has been developed. A variety of synthetically valuable β-alkynylated cyclopentanones were prepared in moderate to good yields. Alkynyl cyclobutanols could also undergo this transformation, providing a new approach to substituted ene-yne-carbonyl compounds.