jo6b02015_si_001.pdf (1.35 MB)
Metal-Free Domino One-Pot Decarboxylative Cyclization of Cinnamic Acid Esters: Synthesis of Functionalized Indanes
journal contribution
posted on 2016-11-16, 00:00 authored by Alavala Gopi Krishna Reddy, Gedu SatyanarayanaTrifluoroacetic
acid promoted unprecedented domino reaction for the synthesis of diverse
indanes starting from simple cinnamic acid esters is described. Their
formation can be explained via acid triggered decarboxylation of cinnamic
acid esters and subsequent inter/intramolecular cyclization. Overall
process involves in the intramolecular cleavage of two σ-bonds
(C–O and C–C) and inter/intramolecular construction
of two/one C–C σ-bond(s). Significantly, this protocol
was successful without the aid of any metal salts.
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