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Download fileMechanochemical Synthesis of Ketones via Chemoselective Suzuki–Miyaura Cross-Coupling of Acyl Chlorides
journal contribution
posted on 2022-03-17, 14:33 authored by Jin Zhang, Pei Zhang, Yangmin Ma, Michal SzostakThe direct synthesis of ketones via
acyl Suzuki–Miyaura
cross-coupling of widely available acyl chlorides is a central transformation
in organic synthesis. Herein, we report the first mechanochemical
solvent-free method for highly chemoselective synthesis of ketones
from acyl chlorides and boronic acids. This acylation reaction is
conducted in the solid state, in the absence of potentially harmful
solvents, for a short reaction time and shows excellent selectivity
for C(acyl)–Cl bond cleavage.