posted on 2021-08-18, 15:36authored byChristian Schumacher, Claude Molitor, Sabrina Smid, Khai-Nghi Truong, Kari Rissanen, Carsten Bolm
A mechanochemical
van Leusen pyrrole synthesis with a base leads
to 3,4-disubstitued pyrroles in moderate to excellent yields. The
developed protocol is compatible with a range of electron-withdrawing
groups and can also be applied to the synthesis of oxazoles. Attempts
to mechanochemically convert the resulting pyrroles into porphyrins
proved to be difficult.