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Download fileMechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway
journal contribution
posted on 01.04.2019, 00:00 authored by Zhengying Gu, Tianqing Liu, Jie Tang, Yannan Yang, Hao Song, Zewen K. Tuong, Jianye Fu, Chengzhong YuIron oxide nanoparticles
(IONPs) have emerging anticancer applications
via polarizing tumor-associated macrophages from tumor-promoting phenotype
(M2) to tumor-suppressing phenotype (M1). However, the underlying
mechanism and structure–function relationship remain unclear.
We report magnetite IONPs are more effective compared to hematite
in M1 polarization and tumor suppression. Moreover, magnetite IONPs
specifically rely on interferon regulatory factor 5 signaling pathway
for M1 polarization and down-regulate M2-assoicated arginase-1. This
study provides new understandings and paves the way for designing
advanced iron-based anticancer technologies.
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tumor-promoting phenotypereport magnetite IONPsanticancer applicationsfactor 5down-regulate M 2-assoicated arginase -1.iron-based anticancer technologiesmagnetite IONPstumor-associated macrophagesSignaling Pathway Iron oxide nanoparticlesM 1 polarizationtumor suppressionIron Oxide-Induced Macrophage Activation