Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway
journal contributionposted on 01.04.2019, 00:00 authored by Zhengying Gu, Tianqing Liu, Jie Tang, Yannan Yang, Hao Song, Zewen K. Tuong, Jianye Fu, Chengzhong Yu
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure–function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.
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tumor-promoting phenotypereport magnetite IONPsanticancer applicationsfactor 5down-regulate M 2-assoicated arginase -1.iron-based anticancer technologiesmagnetite IONPstumor-associated macrophagesSignaling Pathway Iron oxide nanoparticlesM 1 polarizationtumor suppressionIron Oxide-Induced Macrophage Activation