Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer
journal contributionposted on 15.12.2010, 00:00 by Dong Kee Yi, In-Cheol Sun, Ju Hee Ryu, Heebeom Koo, Chul Wan Park, In-Chan Youn, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim, Cheol-Hee Ahn
Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.