bc6b00643_si_001.pdf (1.74 MB)
Download fileMatrix Metalloproteinase Responsive Nanoparticles for Synergistic Treatment of Colorectal Cancer via Simultaneous Anti-Angiogenesis and Chemotherapy
journal contribution
posted on 2016-11-21, 00:00 authored by Leilei Shi, Yi Hu, Ang Lin, Chuan Ma, Chuan Zhang, Yue Su, Linzhu Zhou, Yumei Niu, Xinyuan ZhuColorectal
cancer (CRC) is one of the most commonly diagnosed cancers
worldwide, especially in developed countries. Although patients’
overall survival has been improved by either conventional chemotherapy
or newly developed anti-angiogenesis treatment based on its highly
vascularized feature, the relatively low therapeutic efficacy and
severe side effects remain big problems in clinical practice. In this
study, we describe an easy method to construct a novel matrix metalloproteinase-2
(MMP-2) responsive nanocarrier, which can load hydrophobic agents
(camptothecin and sorafenib) with high efficiency to exert synergistic
efficacy for CRC treatment. The drug-containing nanoparticles can
particularly respond to the MMP-2 and realize the controlled release
of payloads at the tumor site. Moreover, both in vitro and in vivo
studies have demonstrated that this responsive nanoparticle exhibits
much higher therapeutic efficacy than that of single antitumor agents
or combined drugs coadministrated in traditional ways.
History
Usage metrics
Read the peer-reviewed publication
Categories
Keywords
Colorectal CancerChemotherapy Colorectal canceranti-angiogenesis treatmentvivo studiesnovel matrix metalloproteinase -2antitumor agentsnanoparticle exhibitsdrugs coadministratedSynergistic TreatmentefficacyMMP -2tumor siteCRC treatmentdrug-containing nanoparticlesmatrix Metalloproteinase Responsive Nanoparticlesvascularized featureSimultaneous Anti-Angiogenesisside effects