The metabolic disease hyperuricemia (HUA) is characterized
by a
disturbance in purine metabolism. Peptides, such as marine fish-derived
peptides, have previously been shown to be effective in alleviating
HUA. In this study, HUA rats were induced by potassium oxonate with
100 mg/kg (L), 200 mg/kg (M), and 400 mg/kg (H) of marine fish protein
peptide (MFPP). The results showed that MFPP could effectively reduce
the serum uric acid (SUA) levels compared with the model group rats;
kidney histopathology and the levels of inflammatory factors (TNF-α,
IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney
inflammation. Meanwhile, MFPP restored the abundance of beneficial
bacteria, including Lactobacillus, Blautia, Colidextribacter, and Intestinimonas. MFPP further
repaired the intestinal barrier by recovering the expression of gene Ildr2 encoding the tricellular tight junction protein ILDR2
and the immune-related genes Ccr7 and Nr4a3 and also regulated the expression of Entpd8 and Cyp27b1 to restore kidney function and uric acid metabolism.
MFPP was proved to have potential as a therapeutic strategy to be
included in dietary intervention to relieve HUA.