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Manganese-Catalyzed [4 + 2] Annulation of N–H Amidines with Vinylene Carbonate via C–H Activation

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journal contribution
posted on 25.11.2021, 15:33 by Yudong Li, Huan Wang, Ying Li, Yang Li, Yuxia Sun, Chungu Xia, Yuehui Li
Manganese-catalyzed C–H bond functionalization of aryl amidines for the synthesis of 1-aminoisoquinolines in the presence of vinylene carbonate has been developed. The reaction features a broad substrate scope and proceeds under mild reaction conditions with only the carbonate anion as the byproduct.