jm070149m_si_001.pdf (2.25 MB)
Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives
journal contributionposted on 2007-05-17, 00:00 authored by Gary H. Posner, Ik-Hyeon Paik, Wonsuk Chang, Kristina Borstnik, Sandra Sinishtaj, Andrew S. Rosenthal, Theresa A. Shapiro
We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.