jz1c00036_si_001.pdf (506.75 kB)
Magneto-Controlled Enzyme Activity with Locally Produced pH Changes
journal contributionposted on 2021-03-08, 12:33 authored by Krisztina Szekeres, Paolo Bollella, Yongwook Kim, Sergiy Minko, Artem Melman, Evgeny Katz
Biocatalytic activity of amyloglucosidase (AMG), immobilized on superparamagnetic nanoparticles, is dynamically and reversibly activated or inhibited by applying a magnetic field. The magnetic field triggers aggregation/deaggregation of magnetic particles that are also functionalized with urease or esterase enzymes. These enzymes produce a local pH change in the vicinity of the particles changing the AMG activity.