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Magneto-Controlled Enzyme Activity with Locally Produced pH Changes

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journal contribution
posted on 08.03.2021, 12:33 by Krisztina Szekeres, Paolo Bollella, Yongwook Kim, Sergiy Minko, Artem Melman, Evgeny Katz
Biocatalytic activity of amyloglucosidase (AMG), immobilized on superparamagnetic nanoparticles, is dynamically and reversibly activated or inhibited by applying a magnetic field. The magnetic field triggers aggregation/deaggregation of magnetic particles that are also functionalized with urease or esterase enzymes. These enzymes produce a local pH change in the vicinity of the particles changing the AMG activity.