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Download fileMagnetic Photoluminescent Nanoplatform Built from Large-Pore Mesoporous Silica
journal contribution
posted on 2019-04-24, 00:00 authored by Fan Yang, Artiom Skripka, Maryam Sadat Tabatabaei, Sung Hwa Hong, Fuqiang Ren, Yue Huang, Jung Kwon Oh, Sylvain Martel, Xinyu Liu, Fiorenzo Vetrone, Dongling MaIntegrating multiple
components to realize cancer diagnosis and
therapy in a single theranostic nanoplatform has drawn considerable
attention. Herein, a multifunctional theranostic nanoplatform (mSiO2@PbS/CdS-Fe3O4) was successfully fabricated
by carefully designing thiol-modified large-pore mesoporous silica
nanospheres (mSiO2), followed by coordination-driven embedding
of Fe3O4 nanoparticles (NPs) and PbS/CdS quantum
dots (QDs) inside. The excellent feature of near-infrared (NIR) excitation
and NIR emission of PbS/CdS QDs enables deep-tissue photoluminescence
imaging, which was demonstrated ex vivo with tissue as thick as 14
mm. Meanwhile, owing to the presence of superparamagnetic Fe3O4 NPs, mSiO2@PbS/CdS-Fe3O4 can be rapidly confined under an external magnetic field (MF), and
exhibit a significantly high T2 relaxivity
in T2-weighted magnetic resonance (MR)
images in vivo. When mSiO2@PbS/CdS-Fe3O4 was exposed to external physical stimuli of MF and/or NIR
laser, they produced strong local heating through magnetothermal/photothermal
effects. Owing to the unique mesoporous structure of mSiO2@PbS/CdS-Fe3O4, doxorubicin (DOX) was readily
loaded into them and the drug-release profile was subsequently evaluated
under multistimuli (pH/MF/NIR). The release of DOX was significantly
enhanced at lower pH, and higher temperatures caused by magnetothermal/photothermal
effects. Our results pave the road toward developing a highly powerful
nanoplatform for bimodal imaging (NIR deep-tissue photoluminescence
and MR imaging), and simultaneously for integrating synergistic treatment
capabilities of hyperthermia and pH/MF/NIR-responsive drug release.
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Keywords
Large-Pore Mesoporous Silica IntegratingPbSsuperparamagnetic Fe 3 O 4 NPsmSiO 2thiol-modified large-pore mesoporous silica nanospheresFe 3 O 4 nanoparticlesMFmultifunctional theranostic nanoplatformMRMagnetic Photoluminescent NanoplatformDOXpHNIR deep-tissue photoluminescenceT 2 relaxivitydeep-tissue photoluminescence imagingQD