A metal–organic
framework (MOF)-based antibiofouling hemoadsorbent
(PCB-MIL101) was developed through a facile encapsulation of MIL-101(Cr)
in zwitterionic poly carboxybetaine (PCB) hydrogel. PCB-MIL101 possessed
strong mechanical strength and superior hemocompatibility, ensuring
its safety in hemoperfusion applications. In addition, it showed efficient
and effective adsorption toward bilirubin (BR), and its maximum adsorption
capacity was ∼583 mg g–1. Moreover, due to
the protection of antibiofouling PCB hydrogel, PCB-MIL101 showed ability
to resist protein adsorption, thus working effectively to remove BR
molecules from their binding albumin in biological solutions. The
finding in this study provides a novel insight into developing MOF-based
hemoadsorbents for the improvement of hemoperfusion therapies.