ol070249m_si_001.pdf (4.94 MB)
Low-Valent Niobium-Catalyzed Reduction of α,α,α-Trifluorotoluenes
journal contribution
posted on 2007-04-12, 00:00 authored by Kohei Fuchibe, Yoshitaka Ohshima, Ken Mitomi, Takahiko AkiyamaIn the presence of 5 mol % of niobium(V) chloride, α,α,α-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give
toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated.