Low Temperature Organocopper-Mediated Two-Component Cross Coupling/Cycloisomerization Approach Toward N-Fused Heterocycles

Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a “double duty” in this novel cascade transformation, which proceeds via an S_N2′ substitution followed by a subsequent cycloisomerization step.