am0c11627_si_001.pdf (1.79 MB)
Low-Dose X‑ray-Responsive Diselenide Nanocarriers for Effective Delivery of Anticancer Agents
journal contribution
posted on 2020-08-07, 11:33 authored by Lianxue Zhang, Shitong Zhang, Jiaying Xu, Youyun Li, Jinlin He, Ying Yang, Tien Huynh, Peihong Ni, Guangxin Duan, Zaixing Yang, Ruhong ZhouX-ray-responsive
nanocarriers for anticancer drug delivery have
shown great promise for enhancing the efficacy of chemoradiotherapy.
A critical challenge remains for development of such radiation-controlled
drug delivery systems (DDSs), which is to minimize the required X-ray
dose for triggering the cargo release. Herein, we design and fabricate
an effective DDS based on diselenide block copolymers (as nanocarrier),
which can be triggered to release their cargo with a reduced radiation
dose of 2 Gy due to their sensitivity to both X-ray and the high level
of reactive oxygen species (ROS) in the microenvironment of cancer
cells. The underlying molecular mechanism is further illustrated by
proton nuclear magnetic resonance (1H NMR) experiments
and density functional theory (DFT) calculations. In vivo experiments on tumor-bearing mice validated that the loaded drugs
are effectively delivered to the tumor site and exert remarkable antitumor
effects (minimum tumor volume/weight) along with X-ray. Furthermore,
the diselenide nanocarriers exhibit no noticeable cytotoxicity. These
findings provide new insights for the de novo design of radiation-controlled
DDSs for cancer chemoradiotherapy.
History
Usage metrics
Categories
Keywords
cancer chemoradiotherapy2 Gyradiation-controlled drug delivery ...cargo releasediselenide nanocarriers exhibitradiation dosediselenide block copolymerscancer cells1 H NMRROSanticancer drug deliveryradiation-controlled DDSstumor siteX-ray doseDFTAnticancer Agents X-ray-responsive ...tumor-bearing miceantitumor effectsreactive oxygen speciesvivo experimentsEffective Delivery
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC